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For example, higher levels of homocysteine mean that certain proteins important in cardiovascular disease and neurodegenerative diseases can end up with a homocysteine attached or incorporated into them.[ref] The process of post-translational protein modification happens all the time and in a number of different ways, including the addition of other amino acids, sugar molecules, or fatty acids

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This process not only affects normal cell metabolism, but also directly or indirectly damages biological macromolecules, including proteins, lipids, nucleic acids, etc., thus interfering with many aspects of cell signaling, energy production, gene expression, and cell cycle regulation (Tan et al., 2018)