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A principal obstacle to successful CNS therapy is the highly selective BBB, which restricts the passage of nearly 98% low-MW compounds and effectively excludes most macromolecular agents from accessing the brain parenchyma (14)

It was found that MSM administered at 8 mg/kg (just 4 grams for the average-sized horse) significantly reduced exercise-induced oxidative stress in 24 jumping horses

Phytoestrogens, classical antioxidants, and some synthetic compounds, are considered to have a number of beneficial activities, including anticancer, anti-oxidative, anti-inflammatory and estrogenic activity