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Signal 21 (1), 61

There is a separate type of steatosis by which phospholipid accumulation leads to a pattern similar to the diseases with inherited phospholipid metabolism defects (e.g., TaySachs disease) Causes: (a) Microvesicular: Aspirin (Reye's syndrome), ketoprofen, tetracycline (especially if expired) (b) Macrovesicular: Acetaminophen, methotrexate (c) Phospholipidosis: Amiodarone, total parenteral nutrition (d) Antiviral: nucleoside analogues (e) Corticosteroid (f) Hormonal: Tamoxifen Granuloma [edit] Drug-induced hepatic granulomas are usually associated with granulomas in other tissues and patients typically have features of systemic vasculitis and hypersensitivity

Treatment strategies remain limited, focusing on symptomatic management, neuroprotective interventions, and behavioral therapies

2012 Jan;136(1-2):e31-e39.

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