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Delayed plasma clearance of the drug administered orally at a dose of 50 mg/kg was also observed in healthy adults, who required weeks to months before the original clearance rate was achieved with a second dose [22]

It's about ensuring that the one variable you're testingthe effect of the peptide itselfis the only thing influencing your outcome

Urol.1969,101(1), 81-85 38

Summary: This phase 2 trial, a precursor to the phase 3 studies, provided the initial evidence for the superior efficacy of the CagriSema combination