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2012), led us to propose that hepsin could significantly diminish the severity of APAP-induced hepatotoxicity by regulating the abundance of hepatic GJ proteins, which may alter the distribution of free radicals between neighboring hepatocytes, thereby potentially increasing oxidative stress

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Motivation generalizes to other things

Tatsumi Y, Kato A, Kato K, Hayashi H (2018) The interactions between iron and copper in genetic iron overload syndromes and primary copper toxicoses in Japan