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275 In chondrocytes, miR-140 is primarily regulated by SOX9 and targets multiple genes involved in bone and cartilage development, differentiation, and proliferation

Chronic pain lingers for months or years, often because of ongoing inflammation, nerve changes, or tissue that never fully healed

Thus, the increased Alcian Blue signal in our study may reflect GDC-induced exocytosis of preformed mucins rather than transcriptional upregulation

To confirm its safety and effectiveness in extending human life, however, further extensive clinical trials are needed