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In a clinical trial (NCT01919164), intra-articular administration of sprifermin every 6 or 12 months resulted in significant improvements in total femorotibial cartilage thickness after 2 years compared to placebo [430]

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For laboratories conducting long-term studies or maintaining inventory for future projects, colder storage conditions may provide additional protection against degradation

Each injection should be administered on an empty stomach (23 hours after meals, 30 minutes before eating) to maximize GH release [6]