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Targeting this interplay represents a promising therapeutic approach for interrupting the neurodegenerative cascade

A potential role of the gut microbiome in regulating sexually dimorphic opioid response in humans was discussed in a recent review paper [120]

For H&E staining, tissue sections were deparaffinized, rehydrated, and stained with Hematoxylin (H3136, Sigma, Germany) for 5 min followed by Eosin (E4009, Sigma, Germany) for 2 min