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Acknowledgements This work was supported by the NIA (R00AG037574 and R56AG052981), the Prevent Cancer Foundation, the American Institute for Cancer Research (AICR), the American Federation for Aging Research (AFAR) and Einstein Startup Funds to D.M.H

Based on the assumption that a ternary complex is formed between PfGrx, GSH, and roGFP2 WT (S 2 ), we estimated true k red values from tertiary plots at variable GSH concentrations of 7.3 10 5 M 2 s 1 and 1.3 10 5 M 2 s 1 for PfGrx C88S and PfGrx C32S/C88S , respectively (Fig

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First discovered in 1969 by McCord and Fridovich, SOD has since been recognized as an essential component of cellular antioxidant systems

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