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Isoliquiritigenin (ISL), a type of flavonoid, has many health benefits but has poor bioavailability and stability and limits its application in clinical studies

One mechanism which could lead to these properties was suggested to be the binding of beta-3-adrenergic receptors located on white fat and thus increasing the rate of metabolism in fat cells

The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, blood-brain barrierpermeable analog N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide (dihexa)

And so the more you do the sauna or any sort of heat stress, whether it's a hot tub or jacuzzi, you become adapted