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Warszawa, Poland: 2019

10.1046/j.1471-4159.2002.01041.x 181

NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

Some span only part of the membrane associating with a single layer while others stretch from one side of the membrane to the other with either side exposed