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There are a lot of reasons why your ESR may be high that arent catastrophic. Factors That May Affect Your Sed Rate Here are some factors that can affect your ESR directly or indirectly: Your age and sex Your diet Chronic kidney disease Hyperthyroidism Some types of cancer Smoking Extreme obesity The labs measurement technique Women tend to have a higher ESR, largely due to hormone shifts during menstruation, pregnancy, and menopause