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None of this makes the mechanism uninteresting

Symptom-specific management can provide relief: For headaches: paracetamol (following package instructions) and rest in a quiet, darkened room For nausea: small, frequent meals and ginger tea For sleep disturbance: maintain regular sleep schedules and avoid caffeine after midday For anxiety or restlessness: gentle exercise, relaxation techniques, or mindfulness practices Monitoring and communication with your healthcare team is essential

It's whether the research question justifies the added complexity

Due to their small molecular size, they can penetrate the skin as messenger molecules, effectively acting on both the internal and external scalp environment