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International Journal of Medicinal Mushrooms , 25 (12)

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MYC-driven cancer cells exhibit enhanced glutamine utilization accompanied by increased expression of key glutaminolysis enzymes, including GLS1/GLS2 and GLUD1 178,179,180

In PCOS granulosa cells, despite the absence of evidence directly substantiating Cer-mediated pro-senescence effects, this bioactive sphingolipid has been demonstrated to elicit oxidative stress [12], mitochondrial dysfunction [22], and DNA damage [23], all of which are critical drivers of cellular senescence [24]