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Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice

In critical situations, the reduction in plasma glutamine concentration affects the redox state and the metabolism of cells of the immune system, resulting in compromised immune response contributing to the development of sepsis

In contrast, reduced and oxidized glutathione added to blood samples, cells or plasma remained intact

However, their modest efficacy in solid tumors, coupled with metabolic side effects such as insulin resistance and immunosuppression, highlights the need for more selective and context-dependent modulators

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