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In people with MCI, the pattern of brain regions with reduced CBF aligns with regions impacted early in the ADRD pathophysiological cascade (posterior cingulate, parietal, temporal, and hippocampal regions (Zhang H

In line with this, we observed strong positive enrichment for gene signatures related to hepatocyte functions, including cholesterol, fatty acid and drug metabolism, phase II conjugation, clot formation and bile secretion, among others, whereas cell cycle and proliferation signatures were negatively enriched (Fig