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Research focused on investigating severe disease among individuals with high antibody levels has perplexed scientists

Ingenuity pathways analysis (IPA) was applied to demonstrate the molecular and cellular function of the differentially expressed proteins

wherein the presence or increase in copy number, amount, and/or activity of at least one target listed in table 1 and/or the absence or decrease in copy number, amount, and/or activity of at least one target listed in table 2, relative to a control copy number, amount, and/or activity of the at least one target, indicates that the monocyte and/or macrophage can increase its inflammatory phenotype by modulating the at least one target

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Together, this evidence suggests that while mutations or inadequacy of DNA repair mechanisms may play a role in promoting cancer neogenesis and progression, these deficiencies may increase sensitivity of cancer to therapy