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J Neurosci 15:183553, PMID: 7891138 Tanaka K (2000) Functions of glutamate transporters in the brain

Up to 350 mg per day from supplements appears safe, though exceeding this may cause diarrhea

More recent studies have shown that regional depletion of glutamine from PDAC tumors stimulates macropinocytosis by activating EGFR/PAK signaling and supplying glutamine via degradation of extracellular proteins in lysosomes 121

To investigate the depletion of O 2 within the cells, cancer cells in a 1% O 2 atmosphere were treated with Ru(II)-OH, NP2, or NP4, and the O 2 concentration was assessed using the hypoxia probe pimonidazole hydrochloride