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These factors act synergistically to cause glomerular filtration barrier damage and tubulointerstitial fibrosis, ultimately leading to irreversible decline in renal function ( The association between dietary factors and DKD has been supported by substantial epidemiological evidence

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The groups were matched to the best of the researchers abilities, given the limited sample size, and the study was performed in a double-blind crossover manner with a one week washout period

modified oligonucleotide backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages