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Pre-clinical studies done on C57BL/6J mice using total body irradiation (9 Gy) found that radiation reduced -diversity of gut microbiota, while urolithin A (UroA), a gut microbial metabolite, helps in alleviating radiation-induced apoptosis in intestinal cells by suppressing P53 signaling pathway (Zhang et al., 2021c

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The results showed that the expression levels of TaNramp1 , TaNramp5 , TaHMA2 , TaHMA3 , TaLCT1 , and TaIRT2 were greatly induced 13.2-, 17.2-, 16.5-, 11.6-, 10.8- and 1.4-folds by Cd stress in roots compared with CK, respectively (Fig