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A careful skeptic would say: the in-clinic procedure has solid evidence, the at-home extension is biologically plausible and consistent with the procedure, but the dataset is younger than the recommendation implies

Some patients feel the boost the same day

Free Radic Res Commun 3:3338

Furthermore, research has identified unique gene expression profiles in the frontal cortex of individuals with depression, which are closely linked to emotion regulation and cognitive function [375]

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