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In experimental systems, this allows for more reliable analysis of the stimulation of pituitary somatotroph cells and pulsatile growth hormone release

In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

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