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A lyophilized vial requires the user to add the right amount of diluent, mix the product correctly, understand storage instructions after reconstitution and dose from the newly prepared solution

When studies had multiple intervention arms, we treated each arm as a separate arm and divided the number in the comparator by the number of intervention arms to avoid duplicative counting.19 The models returned weekly estimates, which have been converted to monthly rates of regain for ease of interpretation

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A reduced intake of folate and B12 impedes the methylation process, as mentioned above