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Animal evidence suggests this pathway also helps preserve lean mass during weight reduction, although the human data is still maturing

10.1080/15548627.2019.1580105 Autophagy 57 JanevskaD.Chaloska-IvanovaV.JanevskiV

Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)

This review highlights that given the robust preclinical evidence and high public interest, there is a critical need for well-designed human trials to assess the safety, efficacy, and clinical utility of BPC-157 in musculoskeletal medicine

The most effective approaches focus on addressing both the symptoms and the underlying causes of anxiety