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Risk of peripheral neuropathy with prolonged high-dose B6 Pain reduction: Within 3-5 doses Improved sensation: 2-4 weeks Nerve conduction: 6-8 weeks for measurable changes Maximum benefit: After 3 months of regular therapy Effects are cumulative and dose-dependent

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Thus, in these cells, Cys 2 starvation or system x c inhibitor (such as erastin) cannot induce oxidative stress and cell death 26

(2) Preclinicalclinical disconnect: dosing regimens (e.g., colchicine microneedles) lack human PK/PD validation, while transdermal hydrogels need human skin permeability studies to address species-specific stratum corneum variability