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In brain tissue, aconitase is located primarily in the mitochondria where it functions as an enzyme in the tricarboxylic acid cycle

Wong CS, Chang YC, Yeh CC, Huang GS, Cherng CH (2002) Loss of intrathecal morphine analgesia in terminal cancer patients is associated with high levels of excitatory amino acids in the CSF

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Preclinical animal models Given that the recipient microenvironment influences the survival and behavior of transplanted neurons, consideration of specific optic neuropathy models for evaluating RGC transplantation is critical