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Mechanism of Action: It inhibits adrenergic stimulation (alpha- and beta-blocking properties) and affects sodium, potassium, and calcium channels, prolonging the action potential and refractory period in myocardial tissue

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Serum-free or low-serum conditions are essential because serum IGFBPs in the media would partially sequester even LR3 at the highest serum concentrations

Shallower scars like rolling and superficial boxcar scars often respond more dramatically than deep ice pick scars