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In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice (Yang et al., 2023)

6.3.2 PK ceiling and exposure limits Oral bioavailability is a principal barrier for curcumin and several flavonoids

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Example Dose Range: 5002,000 mcg per day with gradual titration

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