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in: PubMed | Google Scholar 1 Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Intrinsic aging is characterized by epidermal thinning, dryness, fine lines, and reduced elasticity over time, whereas extrinsic aging manifests as epidermal thickening, deep wrinkles, skin laxity, roughness, and pigmentation, particularly in sun-exposed areas, such as the face, neck, and hands

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