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SCFAs, especially butyrate, modulate the immune system by activating G-protein-coupled receptors (GPCRs), particularly G-protein-coupled receptor 43 (GPR43) and G-protein-coupled receptor 109A (GPR109A) (169)

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In AD models, it improved memory even when given late, presumably by enhancing histone acetylation and BDNF expression [262]

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