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Trends in Molecular Medicine, 7 , 395403

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Col I expression Since PDGFR activation can lead to excess Col I production, we hypothesize that DHLA can decrease Col I in these cells

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In our hands, when we replaced the MP-081s SAA-NH 2 tail with the A 5 -dA-NH 2 tail (MP-464), we observed a modest improvement in solubility (Table 1), and cellular activity was improved by ~3x (290 vs 880 nM, 10% serum, 16-hour assay, Table 1)