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In the retina, Mller cells perform essential functions for the maintenance of homeostasis, many of which are related to their metabolism, so that energy restriction due to oxidative stress and mitochondrial dysfunction may contribute to the pathogenesis of glaucoma and the loss of RGCs (Kawasaki et al., 2000

However, at early stages of disease development, hepatic metabolites and other compensatory mechanisms may prevent histologic inflammation

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