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This medication can be used as part of a comprehensive approach to pain and inflammation management, complementing other therapies as needed

In ME13, NUP35, NMT2, MTM1, and BCL2 are hub proteins, which are involved in the endomembrane system, while GO term analysis reveals the association of ME13 with endosomal transport, early endosome, and lysosomal membrane (Supplementary Fig

Importantly, this study also demonstrated that the B12 reduction associated with metformin use is not transitory but persists and progresses over time and, in some patients, to levels at which replacement is recommended