Several clinical studies on different human diseases established their tolerability, safety, and toxicity [83, 84]
For example, calcium deficiency has been reported as possibly associated with an increased risk of colorectal or breast cancer ( The relationship between vitamin and mineral supplementation and cancer is still a highly debated topic, considering the widespread use of various supplements and the often-conflicting results reported in the literature ( In this review, we comprehensively discuss the biology and physiology of vitamins and minerals with a specific focus on cancer (Tables 14), aiming to highlight their potential role in cancer prevention based on the available evidence, while also emphasizing the importance of addressing deficiencies during oncologic treatment by providing a practical overview to facilitate their recognition and management
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We then performed a gene set enrichment analysis (GSEA) to determine the association between the expression of ACTL6A and signaling pathways in the RNA array results, which indicated significant differences between ACTL6A-KD cells and control cells in multiple metabolism-related pathways, among which GSH metabolism ranked as one of the most highly correlated pathways (Fig
We therefore hypothesized that PBAT-MPs activate a gut-to-brain inflammatory cascade that induces a lipotoxic microglial phenotype, thereby promoting neurodegeneration
