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This could potentially initiate a cycle of amplified oxidative damage and depletion of antioxidants such as glutathione (GSH) ( 3.2 4-Hydroxynonenal as a cytotoxic effector Hz-triggered peroxidation of polyunsaturated fatty acids (PUFAs) non-enzymatically generates 4-hydroxynonenal (4-HNE), a highly reactive lipid peroxidation end-product (Skorokhod et al., 2005)

These three systems are independent and interact to provide antioxidant effects, the first two system parts were previously described in detail, and we will now focus on the mitochondrial inner membrane enzyme DHODH [68]

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