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Niosomes are next-generation liposomes with cost-effective, simple, and stable manufacturing methods and types include pH-responsive, magnetic, immuno, thermoresponsive, and radio niosomes [120]

Materials and methods Samples collection and ethical approval A total of 20 paraffin-embedded CRC primary tumor samples were obtained from the Department of Pathology of Nanfang Hospital, Southern Medical University, Guangzhou, China