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Studies examining ovariectomized, hormone-primed female rats showed: Dramatic increases in solicitation behaviors (hopping, darting, ear-wiggling) at doses of 100-200 mcg/kg No effects on consummatory behaviors such as lordosis Selective enhancement of proceptive (desire-related) behaviors without affecting receptivity Effects mediated through the medial preoptic area, as direct mPOA injections replicated systemic effects These findings established PT-141 as the first pharmacological agent demonstrating selective appetitive sexual behavior enhancement in preclinical models

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TB-500 has been shown to improve left ventricular function in mice following myocardial infarction, providing compelling evidence that it is beneficial for tissue repair and may mediate cardioprotection [9]

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He suggested that enzymes within 'unknown immunologically competent cells might adapt to antigens which stimulate them to replicate, thus producing antibodies' (Anderson, Mackay)