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It is not known if supplementation with choline will lower the occurrence of NTDs

Injections bypass the gut and deliver B12 directly into circulation, making them particularly effective in these cases

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]