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The resulting BsAb harnesses receptor-mediated transcytosis (RMT) to cross the BBB: after TfR engagement and entry into early endosomes, the antibody is ferried across endothelial cells and released into the parenchyma [118]

Low levels of ROS can activate host cells in the tumor microenvironment, and promote glucose metabolism in tumors to maintain the high energy consumption of tumors by inducing mitochondrial autophagy, altering key enzymes and genes related glucose metabolism and activating signal pathways

This approach not only produces synergistic effects across these levels but also enhances drug delivery efficiency and mucosal retention through the use of natural polymeric materials, thereby comprehensively improving the efficacy of 5-ASA ( FIGURE 2 2.2 Combination of TCM formulations and 5-ASA: holistic multi-target regulation The combination of TCM formulations with 5-ASA demonstrates multidimensional synergistic advantages in clinical efficacy, mechanisms of action, and safety, significantly expanding the scope of disease management beyond conventional 5-ASA monotherapy

Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-B signaling in an Nrf2-dependent manner

examined the stability of different formulations of LNPs loaded with mRNA (mRNA-LNPs) before and after nebulization using a VMN [141]