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John s Wort induces CYP3A4 and can reduce plasma concentrations of PPIs like omeprazole, while curcumin and berberine can inhibit CYP3A4 and P-glycoprotein, raising toxicity risks with drugs such as warfarin, statins, or immunosuppressants

In human DNA, 5-methylcytosine is found in approximately 1.5% of genomic DNA

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