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80 HorzH

Being a potent oxidant, HOCl poses a high reactivity towards biological macromolecules targeting free and protein-associated cysteine, methionine residues and low molecular weight thiols, and its ability to diffuse from the site of generation is very short

Disclosures: Natasha Dilwali: Nothing to Disclose, Robin Howard: Mirum Pharmaceuticals: Stock - publicly traded company, Mirum Pharmaceuticals: Consultant, Mirum Pharmaceuticals: Employee, Mirum Pharmaceuticals: Consultant, Rachel Hallum-Montes: Mirum Pharmaceuticals: Independent Contractor, Yushan Kim: GRAIL: Employee, Mirum Pharmaceuticals: Consultant, Sherlock Biosciences: Consultant, Mammoth Biosciences: Consultant, Douglas Mogul: Nothing to Disclose, Wikrom Karnsakul: Nothing to Disclose 2471 CHILDREN WITH CHRONIC HEPATITIS C HAVE A HIGH PREVALENCE OF NEURODEVELOPMENTAL DISORDERS Shreya Kishore 1 Orlee Guttman 1 , 1 British Columbia Children's Hospital Background: Chronic hepatitis C (HCV) in children is primarily acquired through vertical transmission from an HCV-infected mother

Though the cornea and lens absorb most of the ultraviolet (UV) radiation, a small fraction of it can reach the retina

383 Due to the possible side effects of the anti-TNF therapies, more efforts should be made for more specific anti-TNF therapeutics