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Acknowledgements We thank Dr Mark R Crompton (University of London) for providing the Brk DNA constructs, Dr Steven P Ethier (Karmanos Cancer Institute) for the SUM series of cell lines and Stephanie Deming (Department of Scientific Publications, MD Anderson Cancer Center) for editing the manuscript

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Finally, given the pragmatic nature of the proposed trial, the decision was taken to include consecutive patients seeking medical help at the participating centres, thus ensuring the enrolment of subjects similar to those that would be seen in normal clinical practice

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Tyndale Bulletin