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The difference lies in bioavailability: liposomal capsules encapsulate glutathione in protective liposomes that allow up to 80-90% absorption, whereas regular glutathione tablets are broken down in the digestive tract with much lower absorption, often less than 15%

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This underscores the need for alternative or adjunctive approaches

This suggests that activation of PXR by some drugs may be responsible for the acceleration of vitamin D breakdown through increasing CYP3A4 and CYP24, leading to vitamin D deficiency and, eventually, to bone loss [1]

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