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J Physiol (London) 117: 241250

Collectively, these antioxidants contribute to the overall defense against oxidative stress in the gut, preventing cellular damage and inflammation

Electron microscopy work was performed at the Northwestern University Center for Advanced Microscopy generously supported by NCI CCSG P30 CA060553 awarded to the Robert H Lurie Comprehensive Cancer Center

They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

The authors suggest that serum IGF-1 facilitates brain A removal by enhancing the transport of A carrier proteins (e.g., transthyroxine, apolipoprotein J, and albumin) across the BBB, thereby improving choroid plexus barrier transport and increasing A efflux from the brain, thereby regulating brain A clearance [183, 185]