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In the previous phase I experiment, CB-839 combined with cabozantinib demonstrated good safety and efficacy in the treatment of metastatic renal cell carcinoma (RCC) (Tannir et al., 2018

Numerous experiments on healthy subjects have confirmed the safety and effectiveness of curcumin

Barbiroli, B

Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic neutrophil infiltration observed in IBD