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Abstract Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental health by exacerbating cognitive decline, functional disability, and comorbid chronic diseases

GR catalyzes the conversion of oxidized glutathione (GSSG) to GSH, maintaining high levels of GSH and low levels of GSSG within the organism, thereby preserving an appropriate reducing environment [1, 2]

paracasei from MWKG led to distinct alterations in the expression patterns of genes associated with glucose regulation and lipid homeostasis in the hepatic tissues of treated mice

In patients with chronic obstructive pulmonary disease (COPD), CLA supplementation at a dose of 3.2 g/day for 6 weeks (c9, t11, and c12, t10 isomers in a 50/50 ratio) demonstrated a reduction in serum oxidative stress-related factors, including MDA and matrix metalloproteinase-9 (MMP-9), compared to the placebo group [27], The study suggested that these antioxidant effects were likely a result of the anti-inflammatory properties of CLA, which partly occur through the stimulation of peroxisome proliferator-activated receptors [27]

It adds a different operational layer