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Comment: While many commenters supported the proposed modifications to our cost scoring methodology, many of these commenters requested that CMS implement the cost scoring methodology modification starting with an earlier performance period than we proposed (before the CY 2024 performance period/2026 MIPS payment year)

Among these, the crucial factors are iron accumulation and lipid peroxidation [1, 13] (Table 1)

Furthermore, evidence for changes in the level of blood or tissue mitochondrial function or metabolic readouts is currently lacking for these studies

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