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213,214 Specifically, disturbances in the circadian rhythm not only enhance the malignant potential of breast cancer cells (including their ability for self-renewal, replication, metastasis, and invasion) but also impact chemokine/chemokine receptor signaling (the CXCL12-CXCR4 axis may be the primary signaling pathway) which contributes to the formation of an immunosuppressive microenvironment ultimately leading to tumor progression

Extrapolating from cancer cells performing -oxidation under hyperoxic conditions in vitro to assuming they do so in vivo is akin to judging how fast a fish can run on land by measuring how swiftly it swims in water: the environment fundamentally alters the outcome, misrepresenting the true metabolic behavior of cancer cells within a living organism

Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter

doi: 10.3390/antiox13080985 37

PLGA nanocarriers for better drug delivery in PD Encapsulating pharmacological drugs and natural compounds within nanosystems is reported to significantly enhance the therapeutic potential of treatments for various diseases 90