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The diplomonad intestinal parasite Giardia , which contains homologs of both CIA and ISC pathway components, lacks an ABCB7 homolog (66, 67), suggesting an alternative export route for the NFS1-generated sulfur intermediate (3), or raising the possibility that the two pathways are unconnected in this species The anaerobic protist Pygsuia biforma , lacks an ABCB7 homolog as well as ISC pathway components (68)

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Uptake of the soluble 7ACh receptor/-amyloid complex by astrocytes triggers Ca 2+ influx, followed by glutamate secretion, which induces excitotoxicity and neuronal death (Fig

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