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Tsai YC, Kuo MC, Huang JC, Chang WA, Wu LY, Huang YC, et al

In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)

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found that the siRNA-mediated knockdown of SLC39A14 in murine kidney tubular cells significantly reduced Mn uptake, suggesting that SLC39A14, located in the S3 segment of proximal tubules, plays an important role in Mn absorption in the kidney 65